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IL-7 acts at many levels of T-cell maturation to
support immune responses
IL-7 enriches T-cell function across the cancer immunity cycle
4. Trafficking of T cells to tumors
IL-7 favors T cell tumor infiltration increasing CXCR3 and TGF-β
IL-7 increases T cell counts
CD4 T cells support CD8 T cell function
2. APC cancer antigens presentation
3. Priming activation of T cells
5. Infiltration of T cells into tumors
6. Recognition of cancer cells by T cells
IL-7 increases TCR repertoire diversity and TCR sensitivity to tumor antigens
IL-7 activates T cells to produce IFN-γ
1. Release of cancer antigens
7. Killing of cancer cells
Adapted from Chen Mellman
The Cancer Immunity Cycle
Immunity 39, July 25 2013
IL-7 shapes patients' T cells for immunotherapy success
IFN-γ ELISpot assay: each spot is a lymphocyte producing IFN-γ in response to SARS-Co-V2 antigens
Without IL-7 treatment
With IL-7 treatment
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